AGENDA
TUE 23 APRIL 2024
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Royal College of Physicians of Edinburgh, 11 Queen St, Edinburgh EH2 1JQ
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Chair Martin Taylor, co-chair Michael Nicholson
1400 Plenary Speaker Peter Campbell
1425 Marc Williams: Aneuploidies in normal breast epithelia is common and mirrors the landscape of advanced cancers
1440 Nathaniel Mon Pere: Clonal competition in aging haematopoiesis
1455 Plenary Speaker Martin Taylor
1520 Break Hot drinks and snacks available
1550 Sarah Benedetto: Oligodendrogliomas arise in early childhood and subclonal selection accelerates tumor growth
1605 Natanael Spisak: Disentangling sources of clock-like mutations
1620 Ignaty Leshchiner: Convergent evolution within and across patients reveals mechanisms of cancer drug resistance
1635 Plenary Speaker Inigo Martincorena
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Posters on display in the conference centre
Drinks and finger food available:
Falafel with sweet potato and roast red pepper
Vietnamese wrap (vegetarian)
Sesame roasted aubergine with tofu
Gravadlax, caper and lemon cream cheese
Cider and mustard pork pies
Pulled smokey pork and bean with red cabbage slaw -
Locations for drinks and food in nearby venues have been booked- please register before 22 April: https://www.mutationmeeting.com/activities
WED 24 APRIL 2024
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Hot drinks, pastries, fruit , yoghurt and compote available.
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Chair Veronica Kinsler, co-chair Pei-Chi Wei
0930 Plenary Speaker Tim Coorens
0955 Alexander Steemers: Dissecting the life history of Burkitt Lymphoma
1010 Veronica Busa: Mutation shedding and an anti-tumor niche protects naked mole-rats against cancer
1025 Plenary Speaker Veronica Kinsler: Targeted therapies for Mosaic Disorders
1050 Break Hot drinks and snacks available
1120 Plenary Speaker Joakim Lundeberg
1145 Ailith Ewing: Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer
1200 David Mas Ponte: Identification of somatic mutations during human development from single cell ATAC-seq datasets
1215 Young Seok Ju: Racing epigenetic reprogramming wave in early human embryogenesis inferred from sequencing of clones
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Hot drinks and buffet lunch available:
1. Venison and haggis hot pot
2. Black bean and aubergine chilli with lime sour creamSides: Rice & Seasonal vegetables
Pudding: Salted caramel and bramley apple crumble slice
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Chair Raheleh Rahbari, co-chair Matthew Neville
1400 Aaron Quinlan: Selective dynamics of interruptions at short tandem repeats
1425 Grey Monroe: Evolutionary origins, mechanisms, and consequences of adaptive mutation biases in plants
1440 Meritxell Riera: Life-history determinants of the de novo mutation rate in primates
1455 Plenry Speaker Raheleh Rahbari
1520 Break Hot drinks and snacks available
1550 Candice Young: The Influence of MUTYH on Germline and Somatic Mutagenesis Across Species
1605 Eric Latorrecrespo: Unraveling the temporal dynamics of DNA Methylation Changes
1620 Sarah Aitken: Rerunning tumour evolution reveals germline influences on mutagenesis and cancer susceptibility
1635 Plenary Speaker Anne Goriely
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Posters on display in the Grand Hall- drinks available
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InterContinental Edinburgh the George, 19 - 21 George St, Edinburgh EH2 2PB.
Drinks reception, dinner and dance.
Dress code is smart-casual but aim to be comfortable, with suitable footwear for the dance.
THU 25 APRIL 2024
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Hot drinks, pastries and fruit available.
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Chair Michelle Trenkmann, co-chair Craig Anderson
0930 Benjamin Schuster-Böckler: DNA replication is a source of C to T mutations at methylated cytosine
0945 Sabarinathan Radhakrishnan: Replication stress associated genomic instability at CTCF/Cohesin Binding Sites
1000 Fran Supek: Cell cycle gene alterations associate with a redistribution of mutation rates across chromosomal domains in human cancer
1015 Panel Discussion Michelle Trenkmann
Alex Cagan, Ailith Ewing, Mikkel Heide Schierup & Sarah Aitken
Mutations in time and space – bridging evolutionary biology and translational cancer research1050 Break Hot drinks and snacks available
1120 Plenary Speaker Anna Poetsch: How to decipher the Genetic Code of Instability
1145 Marketa Tomkova: Epigenomics as a key to unlock the mysteries of non-coding cancer drivers
1200 Gilad Evrony: High-fidelity DNA sequencing of the single-strand origins of mutations
1220 Plenary Speaker Kamila Naxerova
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Judge’s choices for best posters and audience vote for best talks