AGENDA

TUE 23 APRIL 2024

  • Royal College of Physicians of Edinburgh, 11 Queen St, Edinburgh EH2 1JQ

  • Chair Martin Taylor, co-chair Michael Nicholson

    1400 Plenary Speaker Peter Campbell

    1425 Marc Williams: Aneuploidies in normal breast epithelia is common and mirrors the landscape of advanced cancers

    1440 Nathaniel Mon Pere: Clonal competition in aging haematopoiesis

    1455 Plenary Speaker Martin Taylor

    1520 Break Hot drinks and snacks available

    1550 Sarah Benedetto: Oligodendrogliomas arise in early childhood and subclonal selection accelerates tumor growth

    1605 Natanael Spisak: Disentangling sources of clock-like mutations

    1620 Ignaty Leshchiner: Convergent evolution within and across patients reveals mechanisms of cancer drug resistance

    1635 Plenary Speaker Inigo Martincorena

  • Posters on display in the conference centre

    Drinks and finger food available:

    Falafel with sweet potato and roast red pepper
    Vietnamese wrap (vegetarian)
    Sesame roasted aubergine with tofu
    Gravadlax, caper and lemon cream cheese
    Cider and mustard pork pies
    Pulled smokey pork and bean with red cabbage slaw

  • Locations for drinks and food in nearby venues have been booked- please register before 22 April: https://www.mutationmeeting.com/activities

WED 24 APRIL 2024

  • Hot drinks, pastries, fruit , yoghurt and compote available.

  • Chair Veronica Kinsler, co-chair Pei-Chi Wei

    0930 Plenary Speaker Tim Coorens

    0955 Alexander Steemers: Dissecting the life history of Burkitt Lymphoma

    1010 Veronica Busa: Mutation shedding and an anti-tumor niche protects naked mole-rats against cancer

    1025 Plenary Speaker Veronica Kinsler: Targeted therapies for Mosaic Disorders

    1050 Break Hot drinks and snacks available

    1120 Plenary Speaker Joakim Lundeberg

    1145 Ailith Ewing: Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

    1200 David Mas Ponte: Identification of somatic mutations during human development from single cell ATAC-seq datasets

    1215 Young Seok Ju: Racing epigenetic reprogramming wave in early human embryogenesis inferred from sequencing of clones

  • Hot drinks and buffet lunch available:

    1. Venison and haggis hot pot
    2. Black bean and aubergine chilli with lime sour cream

    Sides: Rice & Seasonal vegetables

    Pudding: Salted caramel and bramley apple crumble slice

  • Chair Raheleh Rahbari, co-chair Matthew Neville

    1400 Aaron Quinlan: Selective dynamics of interruptions at short tandem repeats

    1425 Grey Monroe: Evolutionary origins, mechanisms, and consequences of adaptive mutation biases in plants

    1440 Meritxell Riera: Life-history determinants of the de novo mutation rate in primates

    1455 Plenry Speaker Raheleh Rahbari

    1520 Break Hot drinks and snacks available

    1550 Candice Young: The Influence of MUTYH on Germline and Somatic Mutagenesis Across Species

    1605 Eric Latorrecrespo: Unraveling the temporal dynamics of DNA Methylation Changes

    1620 Sarah Aitken: Rerunning tumour evolution reveals germline influences on mutagenesis and cancer susceptibility

    1635 Plenary Speaker Anne Goriely

  • Posters on display in the Grand Hall- drinks available

  • InterContinental Edinburgh the George, 19 - 21 George St, Edinburgh EH2 2PB.

    Drinks reception, dinner and dance.

    Dress code is smart-casual but aim to be comfortable, with suitable footwear for the dance.

THU 25 APRIL 2024

  • Hot drinks, pastries and fruit available.

  • Chair Michelle Trenkmann, co-chair Craig Anderson

    0930 Benjamin Schuster-Böckler: DNA replication is a source of C to T mutations at methylated cytosine

    0945 Sabarinathan Radhakrishnan: Replication stress associated genomic instability at CTCF/Cohesin Binding Sites

    1000 Fran Supek: Cell cycle gene alterations associate with a redistribution of mutation rates across chromosomal domains in human cancer

    1015 Panel Discussion Michelle Trenkmann
    Alex Cagan, Ailith Ewing, Mikkel Heide Schierup & Sarah Aitken
    Mutations in time and space – bridging evolutionary biology and translational cancer research

    1050 Break Hot drinks and snacks available

    1120 Plenary Speaker Anna Poetsch: How to decipher the Genetic Code of Instability

    1145 Marketa Tomkova: Epigenomics as a key to unlock the mysteries of non-coding cancer drivers

    1200 Gilad Evrony: High-fidelity DNA sequencing of the single-strand origins of mutations

    1220 Plenary Speaker Kamila Naxerova

  • Judge’s choices for best posters and audience vote for best talks